| Date | Location | Result | |
| Dec 18, 2021 | Bozeman, Mont. | Montana St. 31, South Dakota State 17 | Box score |
| Dec 11, 2021 | Villanova, Pa. | South Dakota State 35, Villanova 21 | Box score |
| Dec 04, 2021 | Sacramento, Calif. | South Dakota State 24, Sacramento St. 19 | Box score |
| Nov 27, 2021 | Brookings, S.D. | South Dakota State 56, UC Davis 24 | Box score |
| Nov 20, 2021 | Brookings, S.D. | South Dakota State 24, North Dakota 21 | Box score |
| Nov 13, 2021 | Vermillion, S.D. | South Dakota 23, South Dakota State 20 | Box score |
| Nov 06, 2021 | Brookings, South Dak | South Dakota State 27, North Dakota St. 19 | Box score |
| Oct 30, 2021 | Youngstown, Ohio | South Dakota State 47, Youngstown State 16 | Box score |
| Oct 23, 2021 | Brookings, S.D. | UNI 26, South Dakota State 17 | Box score |
| Oct 16, 2021 | Macomb, Ill. | South Dakota State 41, Western Illinois 17 | Box score |
| Oct 09, 2021 | Brookings, South Dak | Southern Ill. 42, South Dakota State 41 | Box score |
| Oct 02, 2021 | Brookings, South Dak | South Dakota State 55, Dixie St. 7 | Box score |
| Sep 25, 2021 | Terre Haute, Ind. | South Dakota State 44, Indiana State 0 | Box score |
| Sep 11, 2021 | Brookings, South Dak | South Dakota State 52, Lindenwood (MO) 7 | Box score |
| Sep 03, 2021 | Fort Collins, Colora | South Dakota State 42, Colorado St. 23 | Box score |